Sildenafil Citrate vs. Sildenafil: What's The Difference?
Do not take sildenafil if you are also taking a nitrate drug (such as nitroglycerin or isosorbide dinitrate/mononitrate) for chest pain or heart problems.
- Sildenafil citrate can be combined with lifestyle changes.
- Exercise and weight management improve erectile function.
- Quitting smoking enhances medication effectiveness.
- Reducing alcohol intake minimizes side effects.
- Psychological therapy may support ED treatment.
- Counseling can address underlying emotional issues.
- Regular medical check-ups are recommended.
- Patient education improves safe and effective use.
Do not take sildenafil with recreational drugs such as "poppers".
What to avoid
If you are taking sildenafil (Viagra, Vybrique) for ED, do not take it more than once a day. Take an hour before sexual stimulation (range 30 minutes to 4 hours). If you take it with a high-fat meal it may delay how quickly it starts working. Place sildenafil film on your tongue and allow it to dissolve. If you are taking sildenafil (Revatio) for PAH, take it as directed (the usual dosage is three times daily). Taking these substances together can cause a sudden and dangerous drop in blood pressure. Always buy your ED medications from a reputable supplier as there are a lot of counterfeit products on the market. Certain lifestyle and psychological factors, such as smoking, drinking, and stress, can impact ED.
- Sildenafil can cause sudden vision loss (rare side effect).
- Men with a history of retina problems should use caution.
- It may cause a drop in blood pressure, leading to dizziness.
- Patients should report any persistent erection lasting over 4 hours.
- It is crucial to have proper medical evaluation before use.
- Not suitable for individuals with severe liver or kidney conditions.
- The medication is also investigated for breast cancer treatment.
- Proper hydration can help minimize some side effects.
Eliminating these - for example, staying more active, losing weight if you are overweight, reducing alcohol intake, stopping smoking, and reducing stress - may also help improve ED.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 25mg | 270 + 8 Pills | 184.26€ 175.49€ | |
| Viagra Generic | 200mg | 120 + 8 Pills | 204.80€ 195.05€ | |
| Viagra Generic | 200mg | 360 + 10 Pills | 481.98€ 459.03€ | |
| Kamagra | 100mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Kamagra Soft Tabs | 100mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Viagra Generic | 25mg | 20 Pills | 37.74€ 35.94€ | |
| Viagra Generic | 25mg | 180 + 6 Pills | 154.93€ 147.55€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 150mg | 30 + 2 Pills | 72.32€ 68.88€ | |
| Kamagra Oral Jelly | 100mg | 110 + 9 Sachets | 334.87€ 318.92€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Viagra Generic | 150mg | 60 + 4 Pills | 111.25€ 105.95€ | |
| Viagra Generic | 100mg | 120 + 6 Pills | 149.50€ 142.38€ | |
| Viagra Generic | 200mg | 20 Pills | 61.69€ 58.75€ | |
| Kamagra Oral Jelly | 100mg | 220 + 18 Sachets | 662.24€ 630.70€ | |
| Viagra Generic | 50mg | 60 + 4 Pills | 83.93€ 79.93€ | |
| Viagra Generic | 50mg | 120 + 6 Pills | 129.64€ 123.47€ |
Never take other ED medications at the same time as taking sildenafil. Do not take Viagra while taking Revatio and vice-versa. Seek urgent medical advice if an allergic reaction, sudden vision loss, or painful erections lasting more than four hours occur. Drinking alcohol after taking sildenafil may lower blood pressure and decrease sexual performance.
| Age Group | Approved Usage | Recommended Dose | Additional Comments |
|---|---|---|---|
| 18-65 years | Erectile Dysfunction, PAH | 50-100 mg as needed | Adjust based on response |
| Above 65 years | Use with caution, lower doses possibly | Start at 25-50 mg | Monitor for side effects |
| Under 18 years | Not approved | N/A | Not indicated for minors |
If you are a woman of childbearing age taking sildenafil (brand Revatio) for PAH, then tell your doctor if you become pregnant or are intending to become pregnant. It is not known if sildenafil is distributed into breast milk. Peak plasma concentrations of sildenafil are reached within 30 to 120 minutes of a single dose. Effects of sildenafil, when used for ED, are usually noticeable within 30 to 60 minutes of a single dose. When used to treat PAH, blood pressure-lowering effects are noticeable within one to two hours.
What is sildenafil?
View the USP Certificate or Product Information Sheet in the table above to view additional product details, including available label text and storage information. 1The Harmonized System (HS) code provided on this webpage is for informational purposes only and is subject to change without notice. The exporter and/or importer of record is responsible for determining the accuracy of items at the time of export/import per U.S. regulations. USP is not responsible for the accuracy or completeness of the information furnished.
How does sildenafil work (mechanism of action)?
2USP procures materials worldwide and most foreign materials do not undergo a fundamental change during the packaging process at USP that would substantially transform the item resulting in a country of origin change from the foreign origin to the United States. Under the Rules of Origin the original foreign country of origin would remain. Animal, Plant, Fish) may require special country importation requirements.USP recommends you contact your country competent authorities to determine if any certifications, permits or licenses may be required prior to ordering.Material Origins are found within the Product under Origin Information. Sildenafil is used to treat erectile dysfunction (ED) in men or pulmonary arterial hypertension (PAH) in both men and women, depending on the brand. Viagra and Vybrique are used for ED and Revatio is used for PAH.
Sildenafil Oral Film for ED
Sildenafil works by blocking the action of an enzyme called cGMP-specific phosphodiesterase type-5 (PDE-5). This enzyme breaks down cGMP, a substance that induces smooth muscles to relax. Blocking PDE-5 means increased levels of cGMP within the smooth muscles which promotes muscle relaxation and vasodilation (a widening of blood vessels). High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of the blood vessels and muscles. Medicines that interact with sildenafil may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with sildenafil. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.
| Parameter | Frequency | Purpose | Notes |
|---|---|---|---|
| Blood Pressure | Before and after dosage | Check for hypotension | Especially in high-risk groups |
| Visual Function | Periodic | Monitor for retinal issues | Baseline and follow-up |
| Liver Function Tests | As needed | Detect hepatotoxicity | For long-term users |
Sildenafil is metabolized mainly by CYP3A4 and to some extent by CYP2C9. It also weakly inhibits CYP1A2, 2C(, 2C19, 2D^, 2E1, and 3A4. Any drug that is a substrate of one of these enzymes could potentially interact with sildenafil. In addition, taking sildenafil with too much alcohol can lead to orthostatic hypotension, which is a drop in blood pressure when you go from a sitting or lying down position to standing. Symptoms include a headache, dizziness, or fainting when standing. Antacids, such as magnesium hydroxide or aluminum hydroxide may also affect the absorption of sildenafil.
More about sildenafil
You can take it either with or without food. Do not consume grapefruit or grapefruit products while taking sildenafil. Always talk to your doctor before taking ANY medication for ED. Some ED medications are not suitable for men with certain medical conditions, and your doctor can advise you on an alternative. Call your doctor immediately if you experience dizziness or feel nauseous during sexual activity, or develop pain, numbness, or tingling in your chest, arms, neck, or jaw. Grapefruit juice may also increase the side effects of sildenafil.
| Effect | Mechanism | Onset Time | Duration |
|---|---|---|---|
| Vasodilation | Increased cGMP in smooth muscle | 30 mins | 4-6 hours |
| Blood Pressure Reduction | Vasodilation effects | Rapid | Several hours |
| Enhanced Erectile Function | Increased blood flow to penis | 30 mins | Up to 4-6 hours |
Note that this list is not all-inclusive and includes only common medications that may interact with sildenafil.
Detection in biological fluids
The risk is greater in people aged older than 50, with diabetes, heart disease, high blood pressure, high cholesterol, who smoke, or with certain pre-existing eye problems. Rarely, may cause other side effects or lead to painful erections lasting longer than four hours. See your doctor immediately if this happens. May not be suitable for some people including those with angina, chest pain, other heart conditions, liver or kidney problems, blood or bleeding disorders, stomach ulcers, certain eye conditions, or a physical deformity of the penis (such as Peyronie's disease). Higher dosages of sildenafil are associated with a higher risk of death in children with PAH.
Biochem/physiol Actions
For this reason, the FDA does not recommend use in children aged less than 18 years. May interact with some medications including certain antibiotics and antifungals, herbal remedies, HIV medicines, nitrates, and drugs used in the treatment of high blood pressure or prostate disorders. Sildenafil should not be taken with other PDE-5 inhibitors. The dosage may need to be reduced in people with kidney or liver disease. More research is needed to establish if sildenafil has a role in sexual dysfunction in women.
IV Administration
Sildenafil offers no protection against sexually transmitted diseases. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Sildenafil is used to treat erectile dysfunction (ED) (Viagra, Vybrique brands, generic) and to reduce blood pressure in pulmonary arterial hypertension (PAH) (Revatio brand). It is taken when needed for ED approximately 1 hour before sexual stimulation (maximum dose once daily) and daily for PAH. A headache, stomach upsets, and flushing are the main side effects, and it should white sildenafil tablets not be taken within 24 hours of a nitrate. You should refer to the prescribing information for sildenafil for a complete list of interactions. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use sildenafil only for the indication prescribed. Sometimes a brand name is so popular that it becomes synonymous with an item.
Non-medical use
Sildenafil belongs to the drug class called phosphodiesterase (PDE) type 5 inhibitors. Sildenafil (Viagra, Vybrique brands and generic) is used to treat erectile dysfunction (ED, impotence). It increases blood flow to the penis following sexual stimulation by blocking the enzyme responsible for the breakdown of cGMP. This allows men to keep an erection hard enough for sex. Sildenafil (Viagra, Vybrique brands and generic) only works following sexual stimulation.
Jet lag research
It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity. Sildenafil (Revatio brand) reduces high blood pressure associated with pulmonary arterial hypertension (PAH). This improves the ability to exercise in people with PAH and delays any worsening of their symptoms. When used to treat PAH, sildenafil is available as tablets (20 mg) for and an IV injection. When used for ED, sildenafil is available as oral tablets of 25 mg, 50 mg, and 100 mg strengths, or an oral film (Vybrique brand) of 25 mg, 50 mg, 75 mg, and 100 mg strengths.
What dose should be taken?
If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Dyspepsia, flushing, headache, indigestion, muscle or back pain, and visual disturbances are the most common side effects reported. Other side effects include a drop in blood pressure, insomnia, nasal congestion, or a runny nose and nosebleeds. Sudden hearing loss has also been reported. Some people taking sildenafil have had bleeding events; however, it has not been established if this is related to sildenafil use. Rarely, may decrease blood flow to the optic nerve causing sudden vision loss. Chapstick instead of lip balm, Jacuzzi instead of hot tub, and Crock Pot instead of slow cooker. Another example of this phenomena is Viagra®. Viagra is the brand name for the medication and active ingredient sildenafil citrate.
- Sildenafil citrate is a medication used primarily to treat erectile dysfunction.
- It belongs to the class of drugs called phosphodiesterase type 5 inhibitors.
- Sildenafil was originally developed to treat angina and hypertension.
- The drug works by increasing blood flow to the penis during stimulation.
- It is commonly sold under the brand name Viagra.
- Sildenafil is available by prescription and as generics.
- The typical dose is 50 mg taken about an hour before activity.
- Common side effects include headaches, flushing, and nasal congestion.
Viagra is just one oral medication option among many that can treat erectile dysfunction. The differences between sildenafil citrate (Viagra) and the generic sildenafil are few in terms of effectiveness, but many in terms of branding. In the late 1980s, Pfizer chemists were researching a new potential treatment for high blood pressure called sildenafil.