Dapoxetine: The On-Demand Treatment for PE
Think back on your relationships and sexual encounters since you became sexually active. Have you had problems with premature ejaculation before? Write down any other medical conditions with which you've been diagnosed, including mental health conditions. Also note the names and strengths of all medications you are currently taking or have recently taken, including prescription drugs and those you buy without a prescription. Questions sex tablet 100mg to ask your health care provider. Write down questions in advance to make the most of your time with your provider. The list below suggests questions to ask your health care provider about premature ejaculation.
Topical anesthetics
Tramadol (Ultram, Conzip, Qdolo) is a medication used to treat pain. It also has side effects that delay ejaculation. Tramadol might be prescribed when SSRIs haven't been effective. Tramadol can't be used in combination with an SSRI. Side effects might include nausea, headache, sleepiness and dizziness.
Premature ejaculation (PE), or now, as it is often referred, rapid ejaculation (RE), is a common medical condition that is tough to define and affects up to 30 percent of men.
Tramadol can become habit-forming when taken long-term. Some medications used to treat erectile dysfunction also might help premature ejaculation. Side effects might include headache, facial flushing and indigestion. These medications might be more effective when used in combination with an SSRI. Research suggests that several drugs might be helpful in treating premature ejaculation. Don't hesitate to ask more questions during your appointment. What may be causing my premature ejaculation? How soon after I begin treatment can I expect improvement? How much improvement can I reasonably expect? Am I at risk of this problem recurring? Is there a generic alternative to the medicine you're prescribing?
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra Soft Tabs | 100mg | 180 + 8 Pills | 425.45€ 405.19€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Viagra Original | 100mg | 14 + 2 Pills | 89.03€ 84.79€ | |
| Kamagra Soft Tabs | 100mg | 84 + 4 Pills | 233.05€ 221.95€ | |
| Kamagra Gold | 100 mg | 360 + 6 Pills | 839.95€ 799.95€ | |
| Viagra Original | 100mg | 120 + 8 Pills | 470.39€ 447.99€ | |
| Viagra Professional | 100mg | 180 + 4 Pills | 337.30€ 321.24€ | |
| Viagra Oral Jelly | 100mg | 90 + 8 Sachets | 258.02€ 245.73€ | |
| Levitra Original | 20mg | 4 Pills | 45.87€ 43.69€ | |
| Viagra Super Active | 100mg | 360 + 30 Pills | 470.93€ 448.50€ | |
| Kamagra Oral Jelly | 100mg | 63 + 7 Sachets | 224.18€ 213.50€ | |
| Levitra Original | 20mg | 34 + 2 Pills | 188.51€ 179.53€ | |
| Kamagra Oral Jelly | 100 mg | 21 Sachets | 95.92€ 91.35€ | |
| Cialis Original | 20mg | 92 + 4 Pills | 377.99€ 359.99€ | |
| Kamagra Gold | 100 mg | 84 + 6 Pills | 264.44€ 251.85€ | |
| Cialis Generic | 40mg | 90 + 6 Pills | 171.35€ 163.19€ | |
| Cialis Generic | 40mg | 10 Pills | 37.79€ 35.99€ |
Are there any brochures or other printed material that I can take home with me? Your health care provider might ask very personal questions and might also want to talk to your partner. To help your provider determine the cause of your problem and the best course of treatment, be ready to answer questions, such as: How often do you have premature ejaculation? When did you first experience premature ejaculation? Do you have premature ejaculation only with a specific partner or partners? Do you experience premature ejaculation when you masturbate?
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Also, they may be prescribed alone or with other treatments. A side effect of certain antidepressants is delayed orgasm. For this reason, selective serotonin reuptake inhibitors (SSRIs) are used to treat premature ejaculation. The SSRI dapoxetine is often used as the first treatment for premature ejaculation in some countries. It's not currently available in the United States.
Sildenafil (Viagra®) for PE
Of the drugs approved for use in the United States, paroxetine seems to be the most effective. These medications usually take 5 to 10 days to begin working. But it might take 2 to 3 weeks of treatment to see the full effect. If SSRIs don't improve the timing of your ejaculation, your health care provider might prescribe the tricyclic antidepressant clomipramine (Anafranil). Side effects of antidepressants might include nausea, perspiration, drowsiness and decreased sex drive. Do you have premature ejaculation every time you have sex? How much are you bothered by premature ejaculation?
Over-the-Counter (OTC) Solutions and What to Avoid
They might also be made of thicker latex. Examples include Trojan Extended Pleasure and Durex Prolong. Creams, gels and sprays that contain a numbing agent — such as benzocaine, lidocaine or prilocaine — are sometimes used to treat premature ejaculation. They're applied to the penis 10 to 15 minutes before sex to reduce sensation and help delay ejaculation. However, a cream containing both lidocaine and prilocaine (EMLA) is available by prescription.
Phosphodiesterase-5 (PDE5) Inhibitors
Although topical numbing agents are effective and well tolerated, they have potential side effects. They may cause decreased feeling and sexual pleasure in both partners. These drugs aren't approved by the Food and Drug Administration to treat premature ejaculation, but some are used for this purpose. They include antidepressants, pain relievers and drugs for erectile dysfunction. These medications might be prescribed for either on-demand or daily use. How much is your partner bothered by premature ejaculation?
- Pills that increase serotonin tend to have longer-lasting effects.
- Men should discuss all medications with their healthcare provider.
- The placebo effect can sometimes influence perceived improvements.
- Overuse of delay pills may lead to decreased natural ability.
- PE pills are one part of a holistic approach including therapy and lifestyle.
How satisfied are you with your current relationship? Are you also having trouble getting and keeping an erection (erectile dysfunction)?
| Pill Type | Effectiveness Rate (%) | Onset of Action | Duration of Effect | User Satisfaction (%) | Notes |
|---|---|---|---|---|---|
| Lidocaine-based sprays | 70-85 | 5-15 mins | 30-60 mins | 75 | Quick, numbing effect |
| Dapoxetine tablets | 60-80 | 1-3 hours | 1-3 hours | 70 | Prescription required |
| Natural supplements | 40-60 | Varies | Varies | 50 | Limited scientific evidence |
| Tramadol off-label | 75 | 30 mins | 2-4 hours | 80 | Additional risks involved |
If so, what medications have you recently started or stopped taking? Deciding to talk with your health care provider is an important step. In the meantime, consider exploring other ways in which you and your partner can connect. Although premature ejaculation can cause strain and anxiety in a relationship, it is a treatable condition.
Analgesic, Opioid
Relationship counseling or sex therapy also might be helpful. There is a problem with information submitted for this request. Review/update the information highlighted below and resubmit the form. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. We use the data you provide to deliver you the content you requested.
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To provide you with the most relevant and helpful information, we may combine your email and website data with other information we have about you. If you are a Mayo Clinic patient, we will only use your protected health information as outlined in our Notice of Privacy Practices. You may opt out of email communications at any time by clicking on the unsubscribe link in the email. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Please, try again in a couple of minutes Several alternative medicine treatments have been studied, including yoga, meditation and acupuncture. Premature ejaculation — Current concepts in the management: A narrative review.
- Some PE pills are designed to be used as needed before sex.
- Side effects vary based on pill composition and individual health.
- It's important to differentiate between temporary and chronic PE.
- Combining pills with mindfulness training can improve sexual control.
- Educating oneself about PE helps in making informed choices.
Disorders of ejaculation: An AUA/SMSNA guide. Pelvic floor muscle training improves erectile dysfunction and premature ejaculation: A systematic review. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5-TR. National Institute of Diabetes and Digestive and Kidney Diseases. Khera M. Treatment of male sexual dysfunction.
- Topical gels can numb nerves and delay ejaculation temporarily.
- Oral pills like dapoxetine are prescription medications for PE.
- Herbal supplements claim to improve stamina and control.
- SSRIs often prescribed off-label to help delay climax.
- Some lifestyle changes, like stress reduction, may improve symptoms.
No names, no logos, no delivery fee. All content on this page has been medically reviewed by: Hassan Thwaini, Clinical Pharmacist and Copywriter, Master of Pharmacy (MPharm) on 30 March, 2026.
| Pill Type | Common Side Effects | Serious Risks | Population Caution | Duration of Side Effects |
|---|---|---|---|---|
| Local Anesthetics | Numbness, irritation | Allergic reactions | Men with allergies to anesthetics | Few hours to a day |
| Prescription Medications | Dizziness, nausea | Serotonin syndrome, depression | Men on SSRIs or antidepressants | Few hours to days |
| Natural Supplements | Gastrointestinal discomfort, headaches | No significant risks | Pregnant or nursing women | Varies |
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This is a treatment for the sleeping disorder narcolepsy. Researchers are studying whether injecting Botox into the muscles that help cause ejaculation can treat premature ejaculation. This approach involves talking with a mental health provider about your relationships and experiences. Sessions can help you reduce performance anxiety and find better ways of coping with stress. Counseling is most likely to help when it's used in combination with drug therapy.
Why isn’t there a specific FDA-approved medicine for premature ejaculation?
With premature ejaculation, you might feel that you lose some of the closeness shared with a sexual partner. You might feel angry, ashamed and upset, and turn away from your partner. Your partner also might be upset with the change in sexual intimacy. Premature ejaculation can cause partners to feel less connected or hurt. Talking about the problem is an important step. You can access your medical team whenever you need to, via phone and email. How we make it possible for you to have longer-lasting sex. Innovative methods of delaying ejaculation enable longer-lasting sex without compromising on pleasure.
| Medication Name | Active Ingredient | Usage Frequency | Typical Dose | Side Effects | Prescription Required | Cost ($) |
|---|---|---|---|---|---|---|
| Dapoxetine | Dapoxetine | As needed | 30 mg before sex | Nausea, dizziness | Yes | 1.5-2.5 |
| SSRIs (off-label) | Sertraline, Paroxetine | Daily | 50-100 mg daily | Fatigue, dry mouth | Yes | 1-2 per pill |
| Tramadol (off-label) | Tramadol | As needed | 50 mg | Drowsiness, nausea | Yes | 0.50-0.80 per pill |
Some treatments delay premature ejaculation by boosting serotonin levels in the body, and others work by gently reducing sensitivity in the penis. Treatments for premature ejaculation can take as little as 10 seconds to start working, and usually last long enough for satisfying sex. Premature ejaculation is a common sexual dysfunction where an individual ejaculates earlier than they’d like during sexual activity.
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However, more research is needed to determine their effectiveness. It's typical to feel embarrassed when talking about sexual problems. But you can trust that your health care provider has had similar conversations with many others. Premature ejaculation is a very common condition. And it's one that can be treated.
Clomipramine (Anafranil)
Being ready to talk about premature ejaculation will help you get the treatment you need to put your sex life back on track. The information below should help you prepare to make the most of your appointment. When you make your appointment, ask if there are any restrictions you need to follow in the time leading up to your visit. How often do you ejaculate before you or your partner would wish? How long after you begin having intercourse do you typically ejaculate? It can cause distress and frustration and can occur for a variety of reasons.
- Some pills are available online but may lack quality control.
- Use of medication should be part of a comprehensive treatment plan.
- Understanding the cause of PE helps tailor the best pill choice.
- Long-term use requires medical guidance to avoid dependency.
- Combining pills with sexual therapy can boost confidence.
Psychological contributors may include anxiety, stress, or relationship issues, while physical factors can range from hormonal imbalances to certain neurological conditions. There are simple ways to treat premature ejaculation and medical intervention can provide individuals with tailored strategies that help solve the issue. Treatment for premature ejaculation often involves a combination of techniques. Behavioural strategies like the stop-start or squeeze techniques can be helpful. Medications such as selective serotonin reuptake inhibitors (SSRIs) or topical anaesthetics may be prescribed. Counselling or therapy can also be beneficial when psychological factors are involved. Specialists in medicine, nutrition, performance, and diagnostics. BSc (Hons) MBBS MRCGP AFHEA MA (Hons) AFMCP I occasionally experienced premature ejaculation during sex. Not every time, but enough that it became something that was weighing on my mind whenever I got intimate with a girl. My life is so much better now that it seems silly to have wasted so much time not being satisfied.